{"id":2715,"date":"2014-06-11T06:25:03","date_gmt":"2014-06-10T21:25:03","guid":{"rendered":"https:\/\/blog.maria-reiko.com\/?p=2715"},"modified":"2021-10-27T11:15:33","modified_gmt":"2021-10-27T02:15:33","slug":"%e5%ae%9f%e3%81%af%e3%83%97%e3%83%a9%e3%82%bb%e3%83%b3%e3%82%bf%e3%81%ab%e3%81%af%ef%bc%93%e7%a8%ae%e9%a1%9e%ef%bc%81%e3%81%9d%e3%81%ae%e5%8a%b9%e6%9e%9c%e3%81%a8%e3%81%af%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/blog.maria-reiko.com\/?p=2715","title":{"rendered":"\u5b9f\u306f\u30d7\u30e9\u30bb\u30f3\u30bf\u306b\u306f\u52d5\u7269\u6027\u4ee5\u5916\u306b\u3082\uff01\u5168\uff13\u7a2e\u985e\u305d\u306e\u9055\u3044\u3068\u52b9\u679c\u3068\u306f\uff1f"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\"><strong>\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3063\u3066\u3000\u4f55\uff1f<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong>\u6c17\u306b\u306a\u308b\u308f\uff5e<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong>\u305d\u3093\u306a\u8cb4\u65b9\u3078<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u6700\u8fd1\u300c\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u30a8\u30ad\u30b9\u300d\u306a\u308b\u3082\u306e\u304c\u51fa\u3066\u304d\u3066<br \/>\n\u305d\u308c\u3063\u3066\u3000\u4f55\uff1f\u300d<br \/>\n\u3068\u3001\u3044\u3046<!--more-->\u8cea\u554f\u304c\u591a\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3054\u5b58\u77e5\u306e\u65b9\u3082\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u306f\u300c\u80ce\u76e4\u300d\u306e\u3053\u3068\u3067\u3057\u305f\u306d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u3046\u3067\u3059\uff01\u54fa\u4e73\u52d5\u7269\u3067\u3082\u306a\u3044\u306e\u306b\u3001\u690d\u7269\u306b\u80ce\u76e4\u304c\u3042\u308b\u3068\u601d\u3044\u307e\u3059\uff1f\u3042\u308b\u308f\u3051\u306a\u3044\u3067\u3059\u306d\u3002<br \/>\n<!--more--><br \/>\n\u3053\u306e\u8868\u73fe\u306f\u3001\u3069\u3046\u3084\u3089\u8a00\u8449\u306e\u30a4\u30e1\u30fc\u30b8\u4f5c\u6226\u3067\u3057\u304b\u306a\u3044\u3067\u3057\u3087\u3046\u306d\u3002\u3068\u3001\u3044\u3046\u4e8b\u3067\u3000\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u306b\u3064\u3044\u3066\u3000\u8abf\u67fb\u3057\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"outline__1\">\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3063\u3066\u3001\u4f55\uff1f<\/h2>\n<p>\u5927\u8c46\u3001\u30e9\u30a4\u9ea6\u3001\u30c8\u30a6\u30e2\u30ed\u30b3\u30b7\u3001\u30a2\u30bb\u30ed\u30e9\u306a\u3069\u304b\u3089\u62bd\u51fa\u3057\u305f\u80da\u306e\u3053\u3068\u3092\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u8a00\u3044\u307e\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u306f\u65b0\u7d20\u6750\u3068\u3057\u3066\u304b\u307c\u3061\u3083\u80ce\u5ea7\u7531\u6765\u306e\u690d\u7269\u30d7\u30e9\u30bb\u30f3\u30bf\u539f\u6599\u3067\u300c\u30e1\u30e9\u30cb\u30f3\u7523\u751f\u6291\u5236\u4f5c\u7528\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u69d8\u4f5c\u7528\u3092\u203b\uff36\uff49\uff54\uff52\uff4f\u306b\u3066\u78ba\u8a8d\u30fb\u30fb\u30fb\uff01\u300d\u306a\u3093\u3066\u3044\u3046\u306e\u3082\u3000\u51fa\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u690d\u7269\u306b\u306f\u5f53\u7136\u3001\u80ce\u76e4\u304c\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u690d\u7269\u306e\u80da\u306b\u300c\u80ce\u5ea7\u300d\u3068\u3044\u3046\u3001\u690d\u7269\u304c\u6210\u9577\u3059\u308b\u6642\u306b\u5b9f\u306e\u6804\u990a\u5206\u3068\u306a\u308b\u90e8\u5206\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u90e8\u5206\u304c\u80ce\u76e4\u3068\u540c\u69d8\u306b<strong>\u82f1\u8a9e\u3067\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u8a00\u3046<\/strong>\u3053\u3068\u304b\u3089\u3001\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u547c\u3070\u308c\u3066\u3044\u308b\u3068\u306e\u3053\u3068\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3\u7fa4\u30fb\u30df\u30cd\u30e9\u30eb\u30fb\u30a2\u30df\u30ce\u9178\u306b\u3088\u308b\u7f8e\u808c\u52b9\u679c\u3092\u671f\u5f85\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3067\u3059\u304c\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u52d5\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u307b\u3069\u306e\u52b9\u679c\u3092\u3042\u3052\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3053\u3068\u306f\u3001\u60f3\u50cf\u306b\u96e3\u304f\u3042\u308a\u307e\u305b\u3093\u306d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u306a\u305c\u304b\u3068\u3044\u3046\u3068\u3001\u52d5\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u304c\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u7406\u7531\u306f\u3001\u54fa\u4e73\u985e\u7279\u6709\u306e\u6210\u9577\u56e0\u5b50\u304c\u3042\u308b\u304b\u3089\u3067\u3001\u3053\u306e\u6210\u9577\u56e0\u5b50\u304c\u808c\u3084\u81d3\u5668\u306a\u3069\u3001\u7d30\u80de\u306e\u65b0\u9673\u4ee3\u8b1d\u3092\u6d3b\u767a\u306b\u3059\u308b\u306e\u3067\u3059\u304c\u3001\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u306b\u306f\u3000\u305d\u3093\u306a\u6210\u9577\u56e0\u5b50\u304c\u5b58\u5728\u3057\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3042\u304f\u307e\u3067\u690d\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u306f\u3001\u30a2\u30df\u30ce\u9178\u30fb\u30df\u30cd\u30e9\u30eb\u30fb\u30d3\u30bf\u30df\u30f3\u306a\u3069\u306b\u3088\u308b\u8c4a\u5bcc\u306a\u6804\u990a\u5206\u306b\u3088\u308b\u7f8e\u5bb9\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3082\u306e\u306e\u3088\u3046\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/blog.maria-reiko.com\/wp-content\/uploads\/2014\/06\/\uff1122.jpg\"><img class=\"alignnone size-full wp-image-2729\" decoding=\"async\" loading=\"lazy\" alt=\"\uff11\" src=\"https:\/\/blog.maria-reiko.com\/wp-content\/uploads\/2014\/06\/\uff1122.jpg\" width=\"320\" height=\"481\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"outline__2\">\u6d77\u6d0b\u6027\u30d7\u30e9\u30bb\u30f3\u30bf<\/h2>\n<p>\u3042\u3068\u3000\u3082\u3046\uff11\u3064\uff01\u52d5\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u985e\u4f3c\u3057\u305f\u3082\u306e\u3067\u306f\u3001\u6d77\u6d0b\u6027\u306e\u30de\u30ea\u30f3\u30d7\u30e9\u30bb\u30f3\u30bf\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u3061\u3089\u306f\u9b5a\u7531\u6765\u306e\u30d7\u30e9\u30bb\u30f3\u30bf\u3067\u3001\u9bad\u306e\u5375\u5de3\u819c\u3092\u7cbe\u88fd\u3057\u305f\u3082\u306e\u3060\u305d\u3046\u3067\u3082\u3061\u308d\u3093\u3000\u3053\u308c\u3082\u9bad\u306b\u80ce\u76e4\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u308c\u3082\u80ce\u76e4\u3068\u540c\u69d8\u3001\u5375\u3092\u80b2\u3066\u308b\u6804\u990a\u6210\u5206\u304c\u8c4a\u5bcc\u306a\u5375\u5de3\u819c\u3068\u3044\u3046\u3082\u306e\u3092\u4f7f\u3063\u3066\u3044\u308b\u3082\u306e\u304c\u30de\u30ea\u30f3\u30d7\u30e9\u30bb\u30f3\u30bf\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30de\u30ea\u30f3\u30d7\u30e9\u30bb\u30f3\u30bf\u306b\u542b\u307e\u308c\u308b\u6804\u990a\u6210\u5206\u306f\u3001\u4eba\u9593\u306e\u4f53\u5185\u3067\u306f\u5408\u6210\u304c\u3067\u304d\u306a\u3044\u5fc5\u9808\u30a2\u30df\u30ce\u9178 9\u7a2e\u985e\u306a\u3069\u300118\u7a2e\u985e\u306e\u30a2\u30df\u30ce\u9178\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30a2\u30df\u30ce\u9178\u304c\u808c\u306b\u826f\u3044\u306e\u306f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u306d\u3002\u305d\u308c\u3092\u30b5\u30d7\u30ea\u3067\u6442\u308b\u3053\u3068\u3068\u540c\u3058\u3088\u3046\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30b5\u30d7\u30ea\u3067\u306a\u304f\u3066\u3082\u3000\u9bad\u306f\u666e\u901a\u306b\u98df\u3079\u3066\u3082\u808c\u306b\u826f\u3044\u3082\u306e\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u56e0\u307f\u306b\u3000\u30de\u30ea\u30ea\u30f3\u306f\u9bad\u306f\u597d\u304d\u3067\u3059\u3057\u3053\u3053\u305e\u3068\u8a00\u3046\u3068\u304d\u306f\u3000\uff13\u65e5\u5f8c\u306b\u306f\u5fc5\u305a\u52b9\u679c\u306e\u51fa\u308b\u98df\u3079\u65b9\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span style=\"font-size: 13px;\"><\/span><\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"outline__3\">\u6210\u5206\u306f\u76ae\u819a\u304b\u3089\u5165\u3089\u306a\u3044<\/h2>\n<p>\u690d\u7269\u3084\u9b5a\u7531\u6765\u306e\u3082\u306e\u306a\u3089\u3000\u98df\u3079\u7269\u3068\u540c\u3058\u306a\u306e\u3067\u3001\u30b5\u30d7\u30ea\u3092\u6442\u53d6\u3057\u305f\u308a\u3059\u308b\u5206\u306b\u3064\u3044\u3066\u306f\u3000\u826f\u3044\u3067\u3057\u3087\u3046\u304c<\/p>\n<p>&nbsp;<\/p>\n<p>\u307e\u3055\u304b\u3001\u30de\u30ea\u30ea\u30f3\u306e\u30d6\u30ed\u30b0\u306e\u8aad\u8005\u69d8\u3067\u3001\u3053\u308c\u3092\u5316\u7ca7\u54c1\u306b\u5229\u7528\u3057\u305f\u3082\u306e\u3092\u4f7f\u304a\u3046\u306a\u3069\u3068\u306f\u601d\u308f\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u98df\u3079\u7269\u306f\u6804\u990a\u5206\u3092\u5438\u53ce\u3057\u307e\u3059\u304c\u5316\u7ca7\u54c1\u306f\u7d4c\u76ae\u3001\u6392\u6cc4\u5668\u5b98\u306f\u6804\u990a\u3092\u5438\u53ce\u3057\u306a\u3044\u306e\u3067\u3001\u3053\u308c\u3092\u754c\u9762\u6d3b\u6027\u5264\u3092\u4f7f\u7528\u3057\u3066\u3000\u7121\u7406\u306b\u76ae\u5185\u306b\u5165\u308c\u308c\u3070\u3001\u808c\u3092\u5f31\u3089\u305b\u3066\u3001\u4e7e\u71e5\u3055\u305b\u305f\u308a\u3001\u30b7\u30df\u306b\u306a\u308b\u3060\u3051\uff01\u3067\u3057\u305f\u306d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5730\u7403\u4e0a\u3067\u3000\u4eba\u306e\u76ae\u819a\u306b\u5099\u308f\u308b\u30d0\u30ea\u30a2\u3092\u901a\u904e\u3067\u304d\u308b\u3082\u306e\u306f\u3001\u6cb9\u6eb6\u6027\u30d3\u30bf\u30df\u30f3A\u304c\u5c11\u3057\u3001\u6bd2\u30ac\u30b9\u3001\u305d\u308c\u304b\u3089\u3000\u52d5\u7269\u6027\u30d7\u30e9\u30bb\u30f3\u30bf\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30d7\u30e9\u30bb\u30f3\u30bf\u5316\u7ca7\u54c1\u3001\u30db\u30eb\u30e2\u30f3\u5316\u7ca7\u54c1\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u305f\u5225\u3067\u304a\u8a71\u3057\u307e\u3059\u306d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"outline__4\">\u7f8e\u808c\u3092\u4f5c\u308b\u305f\u3081\u306b\u306f<\/h2>\n<p>\u6d41\u884c\u306b\u8e0a\u3089\u3055\u308c\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u6210\u5206\u306b\u6d41\u884c\u304c\u3042\u308b\u306e\u306f\u3000\u7269\u3092\u58f2\u308c\u308b\u3088\u3046\u306b\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3064\u307e\u308a\u6210\u5206\u306b\u3082\u30d5\u30a1\u30c3\u30b7\u30e7\u30f3\u6027\u306e\u3088\u3046\u306a\u3082\u306e\u30a8\u30f3\u30bf\u30fc\u30c6\u30a4\u30e1\u30f3\u30c8\u7684\u306a\u8981\u7d20\u3092\u6301\u305f\u305b\u3066\u3044\u308b\u3060\u3051\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4eba\u306e\u4f53\u306b\u3000\u76ae\u819a\u306e\u50cd\u304d\u3084\u4ed5\u7d44\u307f\u306b\u30e2\u30c7\u30eb\u30c1\u30a7\u30f3\u30b8\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u306e\u808c\u306e\u50cd\u304d\u3084\u4ed5\u7d44\u307f\u306b\u9006\u3089\u308f\u306a\u3044\u3067\u3001\u808c\u74b0\u5883\u3092\u6574\u3048\u3000\u808c\u306e\u751f\u307e\u308c\u5909\u308f\u308a\u3092\u52a9\u3051\u308b\u3053\u3068\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u3057\u3066\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u751f\u6d3b\u3002\u898f\u5247\u6b63\u3057\u3044\u751f\u6d3b\u3002\u305d\u308c\u3060\u3051\u3067\u808c\u306f\u5065\u5eb7\u306b\u7f8e\u3057\u304f\u306a\u308c\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6210\u5206\u3084\u7f8e\u5bb9\u306e\u6d41\u884c\u306b\u60d1\u308f\u3055\u308c\u306a\u3044\u5f37\u3055\u3068\u8cb4\u65b9\u306e\u808c\u306e\u7f8e\u3057\u3055\u3001\u5f37\u3055\u306f\u6bd4\u4f8b\u3057\u307e\u3059\u3088\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u203bvitro\u3068\u306f\u3000\uff1din vitro\uff08\u30a4\u30f3\u30fb\u30d3\u30c8\u30ed\uff09\u3068\u306f\u3001<br \/>\n\u5206\u5b50\u751f\u7269\u5b66\u306e\u5b9f\u9a13\u306a\u3069\u306b\u304a\u3044\u3066\u3001\u8a66\u9a13\u7ba1\u5185\u306a\u3069\u306e\u4eba\u5de5\u7684\u306b\u69cb\u6210\u3055\u308c\u305f\u6761\u4ef6\u306e\u4e0b\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<br \/>\n\u8a9e\u6e90\u306f\u30e9\u30c6\u30f3\u8a9e\u3067\u300c\u30ac\u30e9\u30b9\u306e\u4e2d\u3067\u300d\u3001\u610f\u5473\u306f\u300c\u8a66\u9a13\u7ba1\u5185\u3067\u300d\u3002<br \/>\n\u5bfe\u3059\u308b\u3000in vivo\uff08\u30a4\u30f3\u30fb\u30d3\u30dc\uff09\u306e\u7531\u6765\u306f\u30e9\u30c6\u30f3\u8a9e\u3067\u3001\u610f\u5473\u306f\u300c\u751f\u4f53\u5185\u3067\u300d<br \/>\nin vivo\u3067\u306e\u5b9f\u9a13\u306f\u5404\u7a2e\u306e\u6761\u4ef6\u304c\u4eba\u70ba\u7684\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u6761\u4ef6\u3068\u3044\u3046\u610f\u5473\u3067\u3082\u3042\u308a\u307e\u3059\u3002<br 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